(ETonline) What do George Clooney, Gwyneth Paltrow, Will Smith,Denzel Washington and Renee Zellweger have in common?

All five A-list stars will join an impressive lineup of extraordinary lineup of actors, musicians, athletes and journalists participating in the “Stand Up To Cancer” television fundraising event — which will broadcast over several networks including ABC, CBS, FOX, NBC and more.

Other stars such as Jane Lynch, Elizabeth Banks, Emily Deschanel, Bill Hader, Dorothy Hamill, Anne Heche, Cheryl Hines, Rob Lowe, Marlee Matlin, Sam Trammell and more will join the broadcast. Musical guests include Billie Joe Armstrong, The Edge, Lady Antebellum, Leona Lewis, Natasha Bedingfield, Queen Latifah, Martina McBride, Aaron Neville, Dave Stewart and Stevie Wonder.

“The Stand Up To Cancer” (SU2C) telecast will raise funds that will accelerate innovative cancer research. The live, one-hour fundraising event will be simulcast commercial-free on September 10, 2010, at 8/7 central.